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A historical one is thalidomide, James said

Some of these supplements may exert more of an effect than others, but we need more research to say for sure

Many patients stop too soon without guidance, missing simple solutions like dose changes or diet tweaks that could make the process easier

She emphasizes listening to the patient, treating systemic contributors, and combining targeted tools with foundational lifestyle work

The potential protective effects of semaglutide on mental health could be due to weight loss, a decrease in food noise, some combination of the two, or an entirely different mechanism, perhaps related to GLP-1's direct effects on the brain, says Anna Lembke, MD, a psychiatry professor at Stanford Medicine in California